Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
A survey on the algorithm and development of multiple sequence alignment
Multiple sequence alignment (MSA) is an essential cornerstone in bioinformatics, which can
reveal the potential information in biological sequences, such as function, evolution and …
reveal the potential information in biological sequences, such as function, evolution and …
Six reference-quality genomes reveal evolution of bat adaptations
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …
and unique immunity. High-quality genomes are crucial for understanding the molecular …
Perfect and imperfect views of ultraconserved sequences
Across the human genome, there are nearly 500 'ultraconserved'elements: regions of at
least 200 contiguous nucleotides that are perfectly conserved in both the mouse and rat …
least 200 contiguous nucleotides that are perfectly conserved in both the mouse and rat …
Ultraconserved enhancer function does not require perfect sequence conservation
V Snetkova, AR Ypsilanti, JA Akiyama, BJ Mannion… - Nature …, 2021 - nature.com
Ultraconserved enhancer sequences show perfect conservation between human and rodent
genomes, suggesting that their functions are highly sensitive to mutation. However, current …
genomes, suggesting that their functions are highly sensitive to mutation. However, current …
Demographic history, adaptation, and NRAP convergent evolution at amino acid residue 100 in the world northernmost cattle from Siberia
L Buggiotti, AA Yurchenko, NS Yudin… - Molecular Biology …, 2021 - academic.oup.com
Native cattle breeds represent an important cultural heritage. They are a reservoir of genetic
variation useful for properly responding to agriculture needs in the light of ongoing climate …
variation useful for properly responding to agriculture needs in the light of ongoing climate …
Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals
AD Fedorova, SJ Kiniry, DE Andreev, JM Mudge… - Nature …, 2022 - nature.com
The synthesis of most proteins begins at AUG codons, yet a small number of non-AUG
initiated proteoforms are also known. Here we analyse a large number of publicly available …
initiated proteoforms are also known. Here we analyse a large number of publicly available …
Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian Lineages
Toll-like receptors (TLRs) play an important role for the innate immune system by detecting
pathogen-associated molecular patterns. TLR5 encodes the major extracellular receptor for …
pathogen-associated molecular patterns. TLR5 encodes the major extracellular receptor for …
Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine
SU Umu, VM Paynter, H Trondsen, T Buschmann… - Cell Genomics, 2023 - cell.com
The annotation of microRNAs depends on the availability of transcriptomics data and expert
knowledge. This has led to a gap between the availability of novel genomes and high …
knowledge. This has led to a gap between the availability of novel genomes and high …
The genome of the pygmy right whale illuminates the evolution of rorquals
Background Baleen whales are a clade of gigantic and highly specialized marine mammals.
Their genomes have been used to investigate their complex evolutionary history and to …
Their genomes have been used to investigate their complex evolutionary history and to …