The availability of the human genome sequence and tools for interrogating individual
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …

Standard follow-up and symptomatic treatment have allowed most patients with cystic
fibrosis to live to young adulthood. However, many patients still die prematurely from …

INTRODUCTION An intricate balance with our intestinal microbes is pivotal to human health.
A key interface of host-microbial interactions occurs in the mucus that covers the intestinal …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

Members of the genus Pseudomonas inhabit a wide variety of environments, which is
reflected in their versatile metabolic capacity and broad potential for adaptation to fluctuating …

Bone marrow‐derived mesenchymal stem cell (BM‐MSC) transplantation has been
suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous …

Mammalian sperm cells must respond to cues originating from along the female
reproductive tract and from the layers of the egg in order to complete their fertilization …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …