ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …

Identifying the mechanisms underlying the regulation of immune checkpoint molecules and
the therapeutic impact of targeting them in cancer is critical. Here we show that high …

Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …

Background—Although metabolic reprogramming is critical in the pathogenesis of heart
failure, studies to date have focused principally on fatty acid and glucose metabolism …

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell
growth that responds to numerous environmental cues. A key input is amino acids, which act …

The mTORC1 kinase is a master growth regulator that senses numerous environmental
cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino …

Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to
Western diet. Three major food classes that promote acne are: 1) hyperglycemic …