Photodynamic therapy (PDT) can be developed into an important arsenal against cancer; it
is a minimally invasive therapy, which is used in the treatment or/and palliation of a variety of …

Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Photothermal therapy (PTT) utilizes nanoparticles embedded within tumors as exogenous
energy absorbers to convert laser light energy into heat to ablate cancer cells. While PTT is …

It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

The photothermal response of plasmonic nanomaterials can be exploited for a number of
biomedical applications in diagnostics (biosensing and optoacoustic imaging) and therapy …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …