Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

We report on the quantitative proteomic analysis of single mammalian cells. Fluorescence‐
activated cell sorting was employed to deposit cells into a newly developed nanodroplet …

Single-cell proteomics can provide critical biological insight into the cellular heterogeneity
that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet …

Ion mobility (IM) separations have a broad range of analytical applications, but insufficient
resolution often limits their utility. Here, we report on ion mobility separations in a structures …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

A combined data acquisition and data processing strategy for improving the sensitivity and
resolution of ion mobility measurements is described. This strategy is implemented on a …

Here we examine the relationship among resolving power (R p), resolution (R pp), and
collision cross section (CCS) for compounds analyzed in previous ion mobility (IM) …

The human metabolome provides a direct physiological read-out of an individual's actual
health state and includes biomarkers that may predict disease or response to a treatment …

Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent
therapeutics identified to date, but there is currently no way to systematically search the …