The burden of antipsychotic-induced weight gain and metabolic syndrome in children

MR Libowitz, EL Nurmi - Frontiers in Psychiatry, 2021 - frontiersin.org
Antipsychotic medications are critical to child and adolescent psychiatry, from the
stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic …

The microbiota–gut–brain axis and its modulation in the therapy of depression: Comparison of efficacy of conventional drugs and traditional Chinese medicine …

C Bi, S Guo, S Hu, J Chen, M Ye, Z Liu - Pharmacological Research, 2022 - Elsevier
Depression is a common and severe mental disease that places a heavy burden on human
society, which can lead to decreased cognitive function, energy loss, insomnia, and even …

Gut microbiome in schizophrenia and antipsychotic-induced metabolic alterations: a scoping review

R Singh, N Stogios, E Smith, J Lee… - Therapeutic …, 2022 - journals.sagepub.com
Schizophrenia (SCZ) is a severe mental disorder with high morbidity and lifetime disability
rates. Patients with SCZ have a higher risk of developing metabolic comorbidities such as …

Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines

A Gangopadhyay, R Ibrahim, K Theberge… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the world and one of the leading indications for liver transplantation. It is one of the many …

Dietary intake of probiotic fermented milk benefits the gut and reproductive health in mice fed with an obesogenic diet

M Akram, SA Ali, P Behare, G Kaul - Food & Function, 2022 - pubs.rsc.org
Probiotics have been suggested as alternatives to pharmacological drugs in the treatment of
a variety of medical problems, including obesity management, which is often linked to low …

The regulatory effects of second-generation antipsychotics on lipid metabolism: Potential mechanisms mediated by the gut microbiota and therapeutic implications

H Chen, T Cao, B Zhang, H Cai - Frontiers in Pharmacology, 2023 - frontiersin.org
Second-generation antipsychotics (SGAs) are the mainstay of treatment for schizophrenia
and other neuropsychiatric diseases but cause a high risk of disruption to lipid metabolism …

A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves …

D Huang, J Gao, C Li, C Nong, W Huang, X Zheng… - …, 2021 - Springer
Background Olanzapine (OLZ) is one of the most effective atypical antipsychotics but is
associated with severe metabolic side effects, in which the gut microbiota plays an important …

The role of the gut microbiome in weight-gain in schizophrenia patients treated with atypical antipsychotics: Evidence based on altered composition and function in a …

X Fang, C Gao, W Wu, X Hu, M Shao, C Zhou, R Cai… - Psychiatry …, 2023 - Elsevier
Objectives We aimed to explore the interconnection between the weight-gain in
schizophrenia patients with atypical antipsychotic treatment and gut microbiome. Methods …

Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain

L Qian, X He, Y Liu, F Gao, W Lu, Y Fan… - Microbiology …, 2023 - Am Soc Microbiol
Olanzapine is one of the most effective medicines available for stabilizing schizophrenia
spectrum disorders. However, it has been reported to show the greatest propensity for …

Young at gut—turning back the clock with the gut microbiome

H Narasimhan, CC Ren, S Deshpande, KE Sylvia - Microorganisms, 2021 - mdpi.com
Over the past century, we have witnessed an increase in life-expectancy due to public health
measures; however, we have also seen an increase in susceptibility to chronic disease and …