Cellular mechanosensing: getting to the nucleus of it all
GR Fedorchak, A Kaminski, J Lammerding - Progress in biophysics and …, 2014 - Elsevier
Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …
allow the cells to adapt to their physical environment. Examples include muscle growth in …
The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein—protein interaction
Q Zheng, Y Zhao - Biology of the Cell, 2007 - Wiley Online Library
The LIM domain is a cysteine‐and histidine‐rich motif that has been proposed to direct
protein—protein interactions. A diverse group of proteins containing LIM domains have been …
protein—protein interactions. A diverse group of proteins containing LIM domains have been …
Thymus-pineal gland axis: revisiting its role in human life and ageing
R Rezzani, C Franco, R Hardeland… - International Journal of …, 2020 - mdpi.com
For years the thymus gland (TG) and the pineal gland (PG) have been subject of
increasingly in-depth studies, but only recently a link that can associate the activities of the …
increasingly in-depth studies, but only recently a link that can associate the activities of the …
[HTML][HTML] Thymosin β4 inhibits TNF-α-induced NF-κB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
P Qiu, MK Wheater, Y Qiu, G Sosne - The FASEB Journal, 2011 - ncbi.nlm.nih.gov
The mechanisms by which thymosin β 4 (Tβ 4) regulates the inflammatory response to injury
are poorly understood. Previously, we demonstrated that ectopic Tβ 4 treatment inhibits …
are poorly understood. Previously, we demonstrated that ectopic Tβ 4 treatment inhibits …
The mechanical stability of proteins regulates their translocation rate into the cell nucleus
A cell's ability to react to mechanical stimuli is known to be affected by the transport of
transcription factors, the proteins responsible for regulating transcription of DNA into RNA …
transcription factors, the proteins responsible for regulating transcription of DNA into RNA …
Thymosin β4 and angiogenesis: modes of action and therapeutic potential
Here we review the mechanisms by which Thymosin β4 (Tβ4) regulates angiogenesis, its
role in processes, such as wound healing and tumour progression and we discuss in more …
role in processes, such as wound healing and tumour progression and we discuss in more …
Roles and mechanisms of β-thymosins in cell migration and cancer metastasis: an update
S Sribenja, S Wongkham, C Wongkham, Q Yao… - Cancer …, 2013 - Taylor & Francis
β-thymosins, including thymosin β4 (Tβ4), Tβ10, and Tβ15, are a family of highly conserved
5 kDa peptides. They are involved not only in normal cell migration, but also in tumor …
5 kDa peptides. They are involved not only in normal cell migration, but also in tumor …
Increased Plasma Concentrations of Cytoskeletal and Ca2+-Binding Proteins and Their Peptides in Psoriasis Patients
T Plavina, M Hincapie, E Wakshull… - Clinical …, 2008 - academic.oup.com
Background: The mechanisms underlying psoriatic pathogenesis are not fully understood
and might be elucidated by identifying novel disease-related molecular markers, including …
and might be elucidated by identifying novel disease-related molecular markers, including …
Global proteomics-based identification and validation of thymosin Beta-4 X-linked as a prognostic marker for head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern
worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging …
worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging …
Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent
G Sosne, P Qiu, M Kurpakus-Wheater - Clinical ophthalmology, 2007 - Taylor & Francis
Thymosin beta 4 (Tβ4) is a low molecular weight protein present in all cells except
erythrocytes. Although Tβ4 is the major monomeric actin-sequestering peptide in cells and …
erythrocytes. Although Tβ4 is the major monomeric actin-sequestering peptide in cells and …