Cellular mechanosensing: getting to the nucleus of it all

GR Fedorchak, A Kaminski, J Lammerding - Progress in biophysics and …, 2014 - Elsevier
Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein—protein interaction

Q Zheng, Y Zhao - Biology of the Cell, 2007 - Wiley Online Library
The LIM domain is a cysteine‐and histidine‐rich motif that has been proposed to direct
protein—protein interactions. A diverse group of proteins containing LIM domains have been …

Thymus-pineal gland axis: revisiting its role in human life and ageing

R Rezzani, C Franco, R Hardeland… - International Journal of …, 2020 - mdpi.com
For years the thymus gland (TG) and the pineal gland (PG) have been subject of
increasingly in-depth studies, but only recently a link that can associate the activities of the …

[HTML][HTML] Thymosin β4 inhibits TNF-α-induced NF-κB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK

P Qiu, MK Wheater, Y Qiu, G Sosne - The FASEB Journal, 2011 - ncbi.nlm.nih.gov
The mechanisms by which thymosin β 4 (Tβ 4) regulates the inflammatory response to injury
are poorly understood. Previously, we demonstrated that ectopic Tβ 4 treatment inhibits …

The mechanical stability of proteins regulates their translocation rate into the cell nucleus

E Infante, A Stannard, SJ Board, P Rico-Lastres… - Nature physics, 2019 - nature.com
A cell's ability to react to mechanical stimuli is known to be affected by the transport of
transcription factors, the proteins responsible for regulating transcription of DNA into RNA …

Thymosin β4 and angiogenesis: modes of action and therapeutic potential

N Smart, A Rossdeutsch, PR Riley - Angiogenesis, 2007 - Springer
Here we review the mechanisms by which Thymosin β4 (Tβ4) regulates angiogenesis, its
role in processes, such as wound healing and tumour progression and we discuss in more …

Roles and mechanisms of β-thymosins in cell migration and cancer metastasis: an update

S Sribenja, S Wongkham, C Wongkham, Q Yao… - Cancer …, 2013 - Taylor & Francis
β-thymosins, including thymosin β4 (Tβ4), Tβ10, and Tβ15, are a family of highly conserved
5 kDa peptides. They are involved not only in normal cell migration, but also in tumor …

Increased Plasma Concentrations of Cytoskeletal and Ca2+-Binding Proteins and Their Peptides in Psoriasis Patients

T Plavina, M Hincapie, E Wakshull… - Clinical …, 2008 - academic.oup.com
Background: The mechanisms underlying psoriatic pathogenesis are not fully understood
and might be elucidated by identifying novel disease-related molecular markers, including …

Global proteomics-based identification and validation of thymosin Beta-4 X-linked as a prognostic marker for head and neck squamous cell carcinoma

LH Chi, WM Chang, YC Chang, YC Chan, CC Tai… - Scientific reports, 2017 - nature.com
Head and neck squamous cell carcinoma (HNSCC) represents a major health concern
worldwide. We applied the matrix-assisted laser desorption/ionization (MALDI) imaging …

Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent

G Sosne, P Qiu, M Kurpakus-Wheater - Clinical ophthalmology, 2007 - Taylor & Francis
Thymosin beta 4 (Tβ4) is a low molecular weight protein present in all cells except
erythrocytes. Although Tβ4 is the major monomeric actin-sequestering peptide in cells and …