[HTML][HTML] Developments and applications of functional protein microarrays

GD Syu, J Dunn, H Zhu - Molecular & Cellular Proteomics, 2020 - ASBMB
Protein microarrays are crucial tools in the study of proteins in an unbiased, high-throughput
manner, as they allow for characterization of up to thousands of individually purified proteins …

Enzymes involved in AMPylation and deAMPylation

AK Casey, K Orth - Chemical reviews, 2018 - ACS Publications
Posttranslational modifications are covalent changes made to proteins that typically alter the
function or location of the protein. AMPylation is an emerging posttranslational modification …

Mapping transcription factor interactome networks using HaloTag protein arrays

J Yazaki, M Galli, AY Kim, K Nito… - Proceedings of the …, 2016 - National Acad Sciences
Protein microarrays enable investigation of diverse biochemical properties for thousands of
proteins in a single experiment, an unparalleled capacity. Using a high-density system …

Plasma autoantibodies associated with basal-like breast cancers

J Wang, JD Figueroa, G Wallstrom, K Barker… - … Biomarkers & Prevention, 2015 - AACR
Background: Basal-like breast cancer (BLBC) is a rare aggressive subtype that is less likely
to be detected through mammographic screening. Identification of circulating markers …

Immunoproteomic profiling of antiviral antibodies in new-onset type 1 diabetes using protein arrays

X Bian, G Wallstrom, A Davis, J Wang, J Park… - Diabetes, 2016 - Am Diabetes Assoc
The rapid rise in the incidence of type 1 diabetes (T1D) suggests the involvement of
environmental factors including viral infections. We evaluated the association between viral …

[HTML][HTML] Global profiling of Huntingtin-associated protein E (HYPE)-mediated AMPylation through a chemical proteomic approach

M Broncel, RA Serwa, TD Bunney, M Katan… - Molecular & Cellular …, 2016 - ASBMB
AMPylation of mammalian small GTPases by bacterial virulence factors can be a key step in
bacterial infection of host cells, and constitutes a potential drug target. This posttranslational …

[HTML][HTML] Comparative study of autoantibody responses between lung adenocarcinoma and benign pulmonary nodules

J Wang, S Shivakumar, K Barker, Y Tang… - Journal of Thoracic …, 2016 - Elsevier
Introduction The reduction in lung cancer mortality associated with computed tomography
(CT) screening has led to its increased use and a concomitant increase in the detection of …

Structure and function of Fic proteins

CR Roy, J Cherfils - Nature Reviews Microbiology, 2015 - nature.com
Fic proteins are a family of proteins characterized by the presence of a conserved FIC
domain that is involved in the modification of protein substrates by the addition of phosphate …

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

B Gulen, M Rosselin, J Fauser, MF Albers, C Pett… - Nature …, 2020 - nature.com
Various pathogenic bacteria use post-translational modifications to manipulate the central
components of host cell functions. Many of the enzymes released by these bacteria belong …

[HTML][HTML] Monitoring host–pathogen interactions using chemical proteomics

AW Muñoz, W Zhao, SA Sieber - RSC Chemical Biology, 2024 - pubs.rsc.org
With the rapid emergence and the dissemination of microbial resistance to conventional
chemotherapy, the shortage of novel antimicrobial drugs has raised a global health threat …