To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Investigations of biological programs that are controlled by gene transcription have mainly
studied the regulation of transcription factors. However, there are examples in which the …

Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is a member of a family of
transcription coactivators that plays a central role in the regulation of cellular energy …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Cardiac mitochondrial function is altered in a variety of inherited and acquired
cardiovascular diseases. Recent studies have identified the transcriptional coactivator …

Peroxisome proliferator-activated receptor α (PPARα) plays a key role in the transcriptional
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …

We hypothesized that the lipid-activated transcription factor, the peroxisome proliferator-
activated receptor α (PPARα), plays a pivotal role in the cellular metabolic response to …