Inhibition of poly (ADP-ribose) polymerase (PARP) activity induces synthetic lethality in
mutated BRCA1/2 cancers by selectively targeting tumor cells that fail to repair DNA double …

The members of the Poly (ADP‐ribose) polymerase (PARP) superfamily are involved in
several biological processes and, in particular, in the DNA damage response (DDR). The …

BACKGROUND Risk factors for the development of therapy‐related leukemia (TRL), an
often lethal late complication of cytotoxic therapy, remain poorly understood and may differ …

Over the last decade, investigation of Ten-Eleven Translocation 2 (TET2) gene function and
TET2 mutation have become of increasing interest in the field of hematology. This …

Background The present study was designed to test the hypothesis that inactivation of
virtually any component within the pathway containing the BRCA1 and BRCA2 proteins …

Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous
and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2 …

The past decade has seen an explosion of interest in the epigenetics of cancer, with an
increasing understanding that this form of genomic modification plays a critical role in …

DNA methylation of CpG islands around gene transcription start sites results in gene
silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression …

Leukemogenesis is a multistep process in which successive transformational events
enhance the ability of a clonal population arising from hematopoietic progenitor cells to …

Background Therapy related myeloid neoplasms (t-MNs) are complex diseases originating
from an interplay between exogenous toxicities and a susceptible organism. It has been …