Thionated organic compounds as emerging heavy-atom-free photodynamic therapy agents
LA Ortiz-Rodríguez, CE Crespo-Hernández - Chemical Science, 2020 - pubs.rsc.org
This minireview focuses on recent progress in developing heavy-atom-free photosensitizers
based on the thionation of nucleic acid derivatives and other biocompatible organic …
based on the thionation of nucleic acid derivatives and other biocompatible organic …
An emerging molecular design approach to heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia
A novel strategy for designing highly efficient and activatable photosensitizers that can
effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is …
effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is …
Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy
Photodynamic therapy has become an emerging strategy for the treatment of cancer. This
technology relies on the development of photosensitizers (PSs) that convert molecular …
technology relies on the development of photosensitizers (PSs) that convert molecular …
The photophysics of nucleic acids: Consequences for the emergence of life
Absorption of ultraviolet (UV) radiation can trigger a variety of photophysical and
photochemical reactions in nucleic acids. In the prebiotic era, on the surface of the early …
photochemical reactions in nucleic acids. In the prebiotic era, on the surface of the early …
Electronic relaxation pathways in heavy-atom-free photosensitizers absorbing near-infrared radiation and exhibiting high yields of singlet oxygen generation
LA Ortiz-Rodríguez, SJ Hoehn, A Loredo… - Journal of the …, 2021 - ACS Publications
Heavy-atom-free photosensitizers (HAF-PSs) based on thionation of carbonyl groups of
readily accessible organic compounds are rapidly emerging as a versatile class of …
readily accessible organic compounds are rapidly emerging as a versatile class of …
Redox-Triggered Activation of Heavy-Atom-Free Photosensitizer and Implications in Targeted Photodynamic Therapy
A strategy for a redox-activatable heavy-atom-free photosensitizer (PS) based on thiolated
naphthalimide has been demonstrated. The PS exhibits excellent reactive oxygen species …
naphthalimide has been demonstrated. The PS exhibits excellent reactive oxygen species …
Following excited-state chemical shifts in molecular ultrafast x-ray photoelectron spectroscopy
The conversion of photon energy into other energetic forms in molecules is accompanied by
charge moving on ultrafast timescales. We directly observe the charge motion at a specific …
charge moving on ultrafast timescales. We directly observe the charge motion at a specific …
Heavy-atom-substituted nucleobases in photodynamic applications: substitution of sulfur with selenium in 6-thioguanine induces a remarkable increase in the rate of …
Sulfur substitution of carbonyl oxygen atoms of DNA/RNA nucleobases promotes ultrafast
intersystem crossing and near-unity triplet yields that are being used for photodynamic …
intersystem crossing and near-unity triplet yields that are being used for photodynamic …
Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer
VN Nguyen, SJ Park, S Qi, J Ha, S Heo, Y Yim… - Chemical …, 2020 - pubs.rsc.org
Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are
synthesized and studied as potential photosensitizers for one-and two-photon excited …
synthesized and studied as potential photosensitizers for one-and two-photon excited …
Ultrafast processes in upper excited singlet states of free and caged 7-diethylaminothiocoumarin
The photochemistry and photophysics of thiocarbonyl compounds, analogues of carbonyl
compounds with sulfur, have long been overshadowed by their counterparts. However …
compounds with sulfur, have long been overshadowed by their counterparts. However …