Oocyte differentiation into a totipotent cell requires initial germ cell cyst breakdown to form
primordial follicles, recruitment of primordial follicles for development into primary follicles …

The embryonic gonads give rise to one of two morphologically and functionally different
organs, a testis or an ovary. Sex determination is the embryonic process that determines the …

The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …

During the differentiation of the mammalian embryonic testis, two compartments are defined:
the testis cords and the interstitium. The testis cords give rise to the adult seminiferous …

During testis development, fetal Leydig cells increase their population from a pool of
progenitor cells rather than from proliferation of a differentiated cell population. However, the …

Transcription factors in the germline play important roles in ovary formation and
folliculogenesis, and control both oocyte development and somatic cell function. Factor in …

In mammals, the role played by germ cells in ovarian differentiation and folliculogenesis has
been the focus of an increasing number of studies over the last decades. From these …

The gonads arise on the ventromedial surface of each mesonephros. In most birds, female
gonadal development is unusual in that only the left ovary becomes functional, whereas that …

The chromosomal sex of the embryo is established at fertilization. However, 6 weeks elapse
in humans before the first signs of sex differentiation are noticed. Sex differentiation involves …

Production of male offspring in viviparous eutherian mammals requires a sex-determining
mechanism resistant to maternal hormones. This constraint is relaxed in egg-laying species …