[HTML][HTML] Solid implantable devices for sustained drug delivery
E Magill, S Demartis, E Gavini, AD Permana… - Advanced Drug Delivery …, 2023 - Elsevier
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …
administration routes. Oral and injectable drug administration are the most common routes …
Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
Hyaluronic acid methacrylate/pancreatic extracellular matrix as a potential 3D printing bioink for constructing islet organoids
D Wang, Y Guo, J Zhu, F Liu, Y Xue, Y Huang, B Zhu… - Acta biomaterialia, 2023 - Elsevier
Islet transplantation has poor long-term efficacy because of the lack of extracellular matrix
support and neovascularization; this limits its wide application in diabetes research. In this …
support and neovascularization; this limits its wide application in diabetes research. In this …
A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells
The long-term function of transplanted therapeutic cells typically requires systemic immune
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
suppression. Here, we show that a retrievable implant comprising a silicone reservoir and a …
Advanced strategies to thwart foreign body response to implantable devices
Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical
for successful long‐term clinical deployment. The FBR is an inevitable immunological …
for successful long‐term clinical deployment. The FBR is an inevitable immunological …
Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels
In recent years, dynamic,'click'hydrogels have been applied in numerous biomedical
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …
[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …
An inverse-breathing encapsulation system for cell delivery
Cell encapsulation represents a promising therapeutic strategy for many hormone-deficient
diseases such as type 1 diabetes (T1D). However, adequate oxygenation of the …
diseases such as type 1 diabetes (T1D). However, adequate oxygenation of the …
[HTML][HTML] A predictive computational platform for optimizing the design of bioartificial pancreas devices
The delivery of encapsulated islets or stem cell-derived insulin-producing cells (ie,
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …