Epigenetics in obesity and diabetes mellitus: new insights
R Suárez, SP Chapela, L Álvarez-Córdova… - Nutrients, 2023 - mdpi.com
A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …
with T2D have been described as having epigenetic modifications. Epigenetics is the post …
[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …
Self‐Assembled Oligopeptoplex‐Loaded Dissolving Microneedles for Adipocyte‐Targeted Anti‐Obesity Gene Therapy
Advancements in gene delivery systems are pivotal for gene‐based therapeutics in
oncological, inflammatory, and infectious diseases. This study delineates the design of a self …
oncological, inflammatory, and infectious diseases. This study delineates the design of a self …
Recent advances in targeted therapy for inflammatory vascular diseases
K Zhao, Z Zeng, Y He, R Zhao, J Niu, H Sun, S Li… - Journal of Controlled …, 2024 - Elsevier
Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …
substantial strain on healthcare systems and socio-economic aspects. They are closely …
Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseases
R Thiruvengadam, B Venkidasamy… - Chemico-Biological …, 2023 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the
cellular antioxidant defense system at the posttranscriptional level. During oxidative stress …
cellular antioxidant defense system at the posttranscriptional level. During oxidative stress …
Recent advances in drug delivery systems based on natural and synthetic polymes for treating obesity
M Xiao, Z Wang, C Li, K Zhang, Z Hou, S Sun… - International Journal of …, 2024 - Elsevier
Obesity stands as a pervasive global public health issue, posing a formidable threat to
human well-being as its prevalence continues to surge year by year. Presently …
human well-being as its prevalence continues to surge year by year. Presently …
Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators
W Wu, J Zheng, R Wang, Y Wang - Biochemical Pharmacology, 2023 - Elsevier
The progression of metabolic diseases, featured by dysregulated metabolic signaling
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …
Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect
CY Hsu, CC Liao, ZC Lin, A Alalaiwe, E Hwang… - Journal of …, 2024 - Springer
Obesity is a major risk to human health. Adipogenesis is blocked by α-tocopherol and
conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The …
conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The …
Non‐Invasive Detection of Early‐Stage Fatty Liver Disease via an On‐Skin Impedance Sensor and Attention‐Based Deep Learning
K Wang, S Margolis, JM Cho, S Wang… - Advanced …, 2024 - Wiley Online Library
Early‐stage nonalcoholic fatty liver disease (NAFLD) is a silent condition, with most cases
going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non‐invasive …
going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non‐invasive …
[HTML][HTML] Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein …
H Yanagisawa, H Maeda, I Noguchi, M Tanaka… - Redox Biology, 2024 - Elsevier
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of
nonalcoholic fatty liver disease characterised by fat accumulation, inflammation, oxidative …
nonalcoholic fatty liver disease characterised by fat accumulation, inflammation, oxidative …