Epigenetics in obesity and diabetes mellitus: new insights

R Suárez, SP Chapela, L Álvarez-Córdova… - Nutrients, 2023 - mdpi.com
A long-term complication of obesity is the development of type 2 diabetes (T2D). Patients
with T2D have been described as having epigenetic modifications. Epigenetics is the post …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

Self‐Assembled Oligopeptoplex‐Loaded Dissolving Microneedles for Adipocyte‐Targeted Anti‐Obesity Gene Therapy

H Choi, J Hong, Y Seo, SH Joo, H Lim… - Advanced …, 2024 - Wiley Online Library
Advancements in gene delivery systems are pivotal for gene‐based therapeutics in
oncological, inflammatory, and infectious diseases. This study delineates the design of a self …

Recent advances in targeted therapy for inflammatory vascular diseases

K Zhao, Z Zeng, Y He, R Zhao, J Niu, H Sun, S Li… - Journal of Controlled …, 2024 - Elsevier
Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …

Association of nanoparticles and Nrf2 with various oxidative stress-mediated diseases

R Thiruvengadam, B Venkidasamy… - Chemico-Biological …, 2023 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the
cellular antioxidant defense system at the posttranscriptional level. During oxidative stress …

Recent advances in drug delivery systems based on natural and synthetic polymes for treating obesity

M Xiao, Z Wang, C Li, K Zhang, Z Hou, S Sun… - International Journal of …, 2024 - Elsevier
Obesity stands as a pervasive global public health issue, posing a formidable threat to
human well-being as its prevalence continues to surge year by year. Presently …

Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators

W Wu, J Zheng, R Wang, Y Wang - Biochemical Pharmacology, 2023 - Elsevier
The progression of metabolic diseases, featured by dysregulated metabolic signaling
pathways, is orchestrated by numerous signaling networks. Among the regulators, ion …

Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect

CY Hsu, CC Liao, ZC Lin, A Alalaiwe, E Hwang… - Journal of …, 2024 - Springer
Obesity is a major risk to human health. Adipogenesis is blocked by α-tocopherol and
conjugated linoleic acid (CLA). However, their effect at preventing obesity is uncertain. The …

Non‐Invasive Detection of Early‐Stage Fatty Liver Disease via an On‐Skin Impedance Sensor and Attention‐Based Deep Learning

K Wang, S Margolis, JM Cho, S Wang… - Advanced …, 2024 - Wiley Online Library
Early‐stage nonalcoholic fatty liver disease (NAFLD) is a silent condition, with most cases
going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non‐invasive …

[HTML][HTML] Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein …

H Yanagisawa, H Maeda, I Noguchi, M Tanaka… - Redox Biology, 2024 - Elsevier
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of
nonalcoholic fatty liver disease characterised by fat accumulation, inflammation, oxidative …