Taste buds are aggregates of 50–100 polarized neuroepithelial cells that detect nutrients
and other compounds. Combined analyses of gene expression and cellular function reveal …

Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

The emerging picture of taste coding at the periphery is one of elegant simplicity. Contrary to
what was generally believed, it is now clear that distinct cell types expressing unique …

Background Many active pharmaceutical ingredients taste bitter and thus are aversive to
children as well as many adults. Encapsulation of the medicine in pill or tablet form, an …

The molecular machinery for chemosensory transduction in taste buds has received
considerable attention within the last decade. Consequently, we now know a great deal …

An ever increasing number of reports about taste receptors in non-gustatory tissues suggest
that these molecules must have additional functions apart from taste. Of the extraoral tissues …

Trpm5 is a calcium-activated cation channel expressed selectively in taste receptor cells. A
previous study reported that mice with an internal deletion of Trpm5, lacking exons 15–19 …

Taste buds are aggregates of 50–100 cells, only a fraction of which express genes for taste
receptors and intracellular signaling proteins. We combined functional calcium imaging with …

Circumstances in which serotonin (5-HT) and noradrenaline (NA) are altered, such as in
anxiety or depression, are associated with taste disturbances, indicating the importance of …

The ability to identify food that is nutrient-rich and avoid toxic substances is essential for an
animal's survival. Although olfaction and vision contribute to food detection, the gustatory …