Monocytes fundamentally contribute to immune surveillance and the inflammatory response
in immunoinflammatory diseases like atherosclerosis. Recruitment of these cells to the site …

There is no “response” in either the innate or adaptive immune response unless leukocytes
cross blood vessels. They do this through the process of diapedesis, in which the leukocyte …

Breakdown of the blood-brain barrier (BBB) and increased immune cell trafficking into the
central nervous system (CNS) are hallmarks of the pathogenesis of multiple sclerosis (MS) …

Tight junctions are the most apical components of endothelial and epithelial intercellular
cleft. In the endothelium these structures play an important role in the control of paracellular …

Neither the innate nor adaptive immune system “responds” unless leukocytes cross blood
vessels. This process occurs through diapedesis, in which the leukocyte moves in an …

Focal recruitment of monocytes and lymphocytes is one of the earliest detectable cellular
responses in the formation of lesions of atherosclerosis. This localized accumulation of …

Both the innate and adaptive immune responses are dependent on the migration of
leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte …

Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes,
memory T lymphocytes, and natural killer cells. Because other chemokines have similar …

The process of atherosclerosis is a life-threatening disease that affects critical organs
including the heart and brain. It results from the influence of noxious agents associated with …

The adhesive interactions of endothelial cells with each other and the adhesion receptors
that mediate these interactions are probably of fundamental importance to the process of …