The Hippo pathway: regulators and regulations
Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …
Organization and execution of the epithelial polarity programme
E Rodriguez-Boulan, IG Macara - Nature reviews Molecular cell biology, 2014 - nature.com
Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Eukaryotic cells rely on long-lived microtubules for intracellular transport and as
compression-bearing elements. We considered that long-lived microtubules are acetylated …
compression-bearing elements. We considered that long-lived microtubules are acetylated …
Autonomous dynamic control of DNA nanostructure self-assembly
Biological cells routinely reconfigure their shape using dynamic signalling and regulatory
networks that direct self-assembly processes in time and space, through molecular …
networks that direct self-assembly processes in time and space, through molecular …
Mechanical compression drives cancer cells toward invasive phenotype
JM Tse, G Cheng, JA Tyrrell… - Proceedings of the …, 2012 - National Acad Sciences
Uncontrolled growth in a confined space generates mechanical compressive stress within
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
tumors, but little is known about how such stress affects tumor cell behavior. Here we show …
Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
H Zempel, E Thies, E Mandelkow… - Journal of …, 2010 - Soc Neuroscience
Aggregation of amyloid-β (Aβ) and Tau protein are hallmarks of Alzheimer's disease (AD),
and according to the Aβ-cascade hypothesis, Aβ is considered toxic for neurons and Tau a …
and according to the Aβ-cascade hypothesis, Aβ is considered toxic for neurons and Tau a …
Plasticity of cell migration in vivo and in silico
V Te Boekhorst, L Preziosi… - Annual review of cell and …, 2016 - annualreviews.org
Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …
and their extracellular environment. Mechanistic principles that determine single-cell and …
Modulating F‐actin organization induces organ growth by affecting the Hippo pathway
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls
organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves …
organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves …
The Apical Polarity Protein Network in Drosophila Epithelial Cells: Regulation of Polarity, Junctions, Morphogenesis, Cell Growth, and Survival
U Tepass - Annual review of cell and developmental biology, 2012 - annualreviews.org
Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …
Cytoskeletal control of early mammalian development
The cytoskeleton—comprising actin filaments, microtubules and intermediate filaments—
serves instructive roles in regulating cell function and behaviour during development …
serves instructive roles in regulating cell function and behaviour during development …