Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as
first line of defense in the innate arm of the immune system. They capture and destroy …

Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

Venous thromboembolism (VTE) encompasses deep-vein thrombosis (DVT) and pulmonary
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …

Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication.
EVs can be released by every cell type and they can be classified into three major groups …

Virchow's triad is traditionally invoked to explain pathophysiologic mechanisms leading to
thrombosis, alleging concerted roles for abnormalities in blood composition, vessel wall …

Cardiovascular diseases are a leading cause of mortality and morbidity worldwide.
Neutrophils are a component of the innate immune system which protect against pathogen …

Deep venous thrombosis is a frequent, multifactorial disease and a leading cause of
morbidity and mortality. Most of the time deep venous thrombosis is triggered by the …

Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles,
including exosomes, microvesicles and apoptotic bodies, which are released into the …

Reports in the last decade have suggested that the role of platelets in atherosclerosis and its
thrombotic complications may be mediated, in part, by local secretion of platelet-derived …

This review focuses on the role of the venous valves in the genesis of thrombus formation in
venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin …