Abstract CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many
cell types of the body, and a soluble form is present in body fluids. There is longstanding …

Cancer remains as one of the leading cause of death worldwide. The development of cancer
involves an intricate process, wherein many identified and unidentified factors play a role …

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

Hypoxia develops during the growth of solid tumors and influences tumoral activity in
multiple ways. Low oxygen tension is also present in the bone microenvironment where …

Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate
carboxypeptidase expressed in a number of tissues. PSMA participates in various biological …

Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …

Abstract G Protein-Coupled Receptors (GPCRs) represent the largest superfamily of cell-
surface proteins. However, the expression and function of majority of GPCRs remain …

Neuropeptide Y (NPY) is a sympathetic neurotransmitter with pleiotropic actions, many of
which are highly relevant to tumor biology. Consequently, the peptide has been implicated …

Biomarkers are incorporated ubiquitously into clini-cal practice as surrogate endpoints of
physiologic and pathologic processes that cannot be measured directly. For example, a lipid …