Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool
to perform novel biocompatible chemospecific reactions in living systems. Following the …

Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of
therapeutics locally through chemical reactions not accessible by biological systems. This …

5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutics for the treatment of
cancers associated with the aerodigestive tract, breast, and colorectal system. The efficacy …

Bioorthogonal catalysis using transition-metal-based complexes (TMCs) is a promising
approach for converting substrates to desired products in complex cellular media. Notably …

Macrophages migrate to tumor sites by following chemoattractant gradients secreted by
tumor cells, providing a truly active targeting strategy for cancer therapy. However …

Rh-catalysed NH carbene insertion reactions were exported to living cells with help of
amphiphilic polymeric nanoparticles. Hereto, hydrophobic dirhodium carboxylate catalysts …

Bioorthogonal catalysis employing transition metal catalysts is a promising strategy for the in
situ synthesis of imaging and therapeutic agents in biological environments. The transition …

Malignant tumors are a severe threat to human health. Surgical removal is still the preferred
method in clinical practice among the many treatment strategies. Nevertheless, tiny residual …

Bioorthogonal metallocatalysis has opened up a xenobiotic route to perform nonenzymatic
catalytic transformations in living settings. Despite their promising features, most metals are …

The site‐specific activation of bioorthogonal prodrugs has provided great opportunities for
reducing the severe side effects of chemotherapy. However, the precise control of activation …