Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

[HTML][HTML] Epidemiology of osteoarthritis

KD Allen, LM Thoma, YM Golightly - Osteoarthritis and cartilage, 2022 - Elsevier
Objective To summarize the current state of the evidence regarding osteoarthritis (OA)
prevalence, incidence and risk factors at the person-level and joint-level. Design This was a …

Diagnosis and treatment of hip and knee osteoarthritis: a review

JN Katz, KR Arant, RF Loeser - Jama, 2021 - jamanetwork.com
Importance Osteoarthritis (OA) is the most common joint disease, affecting an estimated
more than 240 million people worldwide, including an estimated more than 32 million in the …

[HTML][HTML] Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update

R Giorgino, D Albano, S Fusco, GM Peretti… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

X Chen, W Gong, X Shao, T Shi, L Zhang… - Annals of the …, 2022 - ard.bmj.com
Objective The aim of the study was to investigate the role and regulatory mechanisms of
fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis …

[HTML][HTML] Hyaluronic acid: molecular mechanisms and therapeutic trajectory

RC Gupta, R Lall, A Srivastava, A Sinha - Frontiers in veterinary …, 2019 - frontiersin.org
Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

A systematic review of the incidence, prevalence, costs, and activity and work limitations of amputation, osteoarthritis, rheumatoid arthritis, back pain, multiple sclerosis …

J Lo, L Chan, S Flynn - Archives of physical medicine and rehabilitation, 2021 - Elsevier
Objectives To present recent evidence on the prevalence, incidence, costs, activity
limitations, and work limitations of common conditions requiring rehabilitation. Data Sources …

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

TW O'Neill, PS McCabe, J McBeth - Best practice & research Clinical …, 2018 - Elsevier
Osteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and
disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and …

Ageing and the pathogenesis of osteoarthritis

RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

The burden of osteoarthritis in older adults

GA Hawker, LK King - Clinics in geriatric medicine, 2022 - geriatric.theclinics.com
Osteoarthritis (OA) is a serious disease. The most common form of arthritis, 1 OA typically
affects the hips, knees, hands, feet, and spine, and multijoint involvement is common. 2 OA …