Benzodiazepine use and risk of dementia in the elderly population: a systematic review and meta-analysis

MM Islam, U Iqbal, B Walther, S Atique, NK Dubey… - …, 2017 - karger.com
Background: Benzodiazepines are a widely used medication in developed countries,
particularly among elderly patients. However, benzodiazepines are known to affect memory …

The GABAergic system as a therapeutic target for Alzheimer's disease

B Calvo‐Flores Guzmán, C Vinnakota… - Journal of …, 2018 - Wiley Online Library
Glutamatergic and cholinergic dysfunction are well‐attested features of Alzheimer's disease
(AD), progressing with other pathological indices of the disorder and exacerbating neuronal …

[PDF][PDF] Benzodiazepine use and risk of Alzheimer's disease: case-control study

SB De Gage, Y Moride, T Ducruet, T Kurth, H Verdoux… - Bmj, 2014 - bmj.com
Objectives To investigate the relation between the risk of Alzheimer's disease and exposure
to benzodiazepines started at least five years before, considering both the dose-response …

Benzodiazepine use and risk of dementia: prospective population based study

SB de Gage, B Bégaud, F Bazin, H Verdoux… - Bmj, 2012 - bmj.com
Objective To evaluate the association between use of benzodiazepines and incident
dementia. Design Prospective, population based study. Setting PAQUID study, France …

Benzodiazepine use and risk of incident dementia or cognitive decline: prospective population based study

SL Gray, S Dublin, O Yu, R Walker, M Anderson… - bmj, 2016 - bmj.com
Objective To determine whether higher cumulative use of benzodiazepines is associated
with a higher risk of dementia or more rapid cognitive decline. Design Prospective …

Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study

S Weich, HL Pearce, P Croft, S Singh, I Crome… - Bmj, 2014 - bmj.com
Objective To test the hypothesis that people taking anxiolytic and hypnotic drugs are at
increased risk of premature mortality, using primary care prescription records and after …

Association between benzodiazepine use and dementia: a meta-analysis

GC Zhong, Y Wang, Y Zhang, Y Zhao - PloS one, 2015 - journals.plos.org
Background The association between long-term benzodiazepine use and risk of dementia
remains controversial. Therefore, current study aimed to quantify this association, and to …

Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study

PL Chen, WJ Lee, WZ Sun, YJ Oyang, JL Fuh - PloS one, 2012 - journals.plos.org
Background Hypnotics have been reported to be associated with dementia. However, the
relationship between insomnia, hypnotics and dementia is still controversial. We sought to …

[HTML][HTML] Risk of dementia in long-term benzodiazepine users: evidence from a meta-analysis of observational studies

Q He, X Chen, T Wu, L Li, X Fei - Journal of clinical …, 2019 - synapse.koreamed.org
Background and Purpose There is conflicting evidence in the literature on the association
between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to …

The benzodiazepine–dementia disorders link: current state of knowledge

A Pariente, SB de Gage, N Moore, B Bégaud - CNS drugs, 2016 - Springer
The short-term effects of benzodiazepines on memory are well established and are
suspected in the long term. Eleven studies have been published so far concerning …