DNA microarrays: a powerful genomic tool for biomedical and clinical research

V Trevino, F Falciani, HA Barrera-Saldaña - Molecular medicine, 2007 - Springer
Among the many benefits of the Human Genome Project are new and powerful tools such as
the genome-wide hybridization devices referred to as microarrays. Initially designed to …

Comparing whole genomes using DNA microarrays

D Gresham, MJ Dunham, D Botstein - Nature Reviews Genetics, 2008 - nature.com
The rapid accumulation of complete genomic sequences offers the opportunity to carry out
an analysis of inter-and intra-individual genome variation within a species on a routine …

Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species, and neutrophil extracellular traps

HL Wright, M Lyon, EA Chapman, RJ Moots… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints.
Neutrophils are believed to play an important role in both the initiation and progression of …

Macrophages of distinct origins contribute to tumor development in the lung

PL Loyher, P Hamon, M Laviron… - Journal of Experimental …, 2018 - rupress.org
Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis.
Herein we show that tissue-resident interstitial macrophages (Res-TAMs) in mouse lungs …

[HTML][HTML] Widespread macromolecular interaction perturbations in human genetic disorders

N Sahni, S Yi, M Taipale, JIF Bass… - Cell, 2015 - cell.com
How disease-associated mutations impair protein activities in the context of biological
networks remains mostly undetermined. Although a few renowned alleles are well …

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

C Schneider, SP Nobs, M Kurrer, H Rehrauer… - Nature …, 2014 - nature.com
Tissue-resident macrophages constitute heterogeneous populations with unique functions
and distinct gene-expression signatures. While it has been established that they originate …

Precise and reliable gene expression via standard transcription and translation initiation elements

VK Mutalik, JC Guimaraes, G Cambray, C Lam… - Nature …, 2013 - nature.com
An inability to reliably predict quantitative behaviors for novel combinations of genetic
elements limits the rational engineering of biological systems. We developed an expression …

Ex-situ biogas upgrading and enhancement in different reactor systems

PG Kougias, L Treu, DP Benavente, K Boe… - Bioresource …, 2017 - Elsevier
Biogas upgrading is envisioned as a key process for clean energy production. The current
study evaluates the efficiency of different reactor configurations for ex-situ biogas upgrading …

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

L Yang, C Lin, C Jin, JC Yang, B Tanasa, W Li… - Nature, 2013 - nature.com
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in
physiological aspects of cell-type determination and tissue homeostasis, their potential …

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus

E Villanueva, S Yalavarthi, CC Berthier… - The Journal of …, 2011 - journals.aai.org
An abnormal neutrophil subset has been identified in the PBMC fractions from lupus
patients. We have proposed that these low-density granulocytes (LDGs) play an important …