Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …

Extracellular vesicles (EVs) derived from mesenchymal stem cells are promising
nanotherapeutics in liver diseases due to their regenerative and immunomodulatory …

Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid
peroxidation. However, the molecular mechanisms regulating ferroptosis are largely …

An increasing number of studies have shown that air pollution containing particulate matter
(PM)≤ 2.5 µm (PM2. 5) plays a significant role in the development of metabolic disorder and …

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory
mechanisms are not fully understood. In the current study, we reported that the BRD7-P53 …

Background Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate
of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however …

Pyroptosis is a newly discovered form of cell death. Peroxiredoxin 3 (PRX3) plays a crucial
role in scavenging reactive oxygen species (ROS), but its hepatoprotective capacity in …

Introduction High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD)
by promoting chronic inflammation. However, the mechanisms are poorly understood …

Liver macrophages (LMs) have been proposed to contribute to metabolic disease through
secretion of inflammatory cytokines. However, anti-inflammatory drugs lead to only modest …

Rationale: Liver resection and transplantation surgeries are accompanied by hepatic
ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery. Given that the …