Introduction Hematologic toxicity (HT), particularly leukopenia, is a common side-effect of
oncologic treatments for pelvic malignancies. Pelvic nodal radiotherapy (PNRT) has been …

Background In patients with squamous cell carcinoma of the anus (SCCA), lymph node
positivity (LNP) indicates poor prognosis for survival and is central to radiotherapy planning …

Abstract Aim Six Phase III randomized trials have determined the effectiveness of
chemoradiotherapy as primary treatment for anal squamous cell carcinoma (ASCC), but …

Background Although treatment‐related lymphopenia (TRL) is common and associated with
poorer survival in multiple solid malignancies, few data exist for anal cancer. We evaluated …

Background and purpose This systematic review summarised and critically appraised
evidence on the efficacy and safety of interventions for anal cancer to support the panel of …

Although anal squamous cell carcinoma (ASCC) is an uncommon malignancy, its incidence
has been increasing markedly in recent decades due to its association with human …

Purpose Hematologic toxicity (HT) during chemoradiation therapy (CRT) for anal cancer can
lead to treatment breaks that compromise efficacy. We hypothesized that CRT-induced HT …

Anal cancer is an uncommon malignancy whose incidence has been rising over the past
several decades. 1 In 2016, it is expected that more than 8000 new cases of anal cancer will …

Background: To evaluate local control (LC), survival and toxicity in anal cancer patients
treated with intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy at a …

The incidence of anal cancer in the United States has increased in recent years, primarily
related to the increasing incidence of HPV-associated anal squamous cell carcinoma, which …