Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

G-protein-coupled receptors have a major role in transmembrane signalling in most
eukaryotes and many are important drug targets. Here we report the 2.7 Å resolution crystal …

The complement system plays an important role in the innate immune response to invading
pathogens. The complement fragment C5a is one of its important effector components and …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

GPCRs exhibit a common architecture of seven transmembrane helices (TMs) linked by
intracellular loops and extracellular loops (ECLs). Given their peripheral location to the site …

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant
and contains features essential for coreceptor binding. We determined the structure of V3 in …

The importance of β-adrenergic signaling in the heart has been well documented, but it is
only more recently that we have begun to understand the importance of this signaling …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …