Many multicellular eukaryotes have reasonably high per-generation mutation rates.
Consequently, most populations harbor an abundance of segregating deleterious alleles …

Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …

Epistatic interactions between mutations play a prominent role in evolutionary theories.
Many studies have found that epistasis is widespread, but they have rarely considered …

To an evolutionary geneticist, the most important property of a new mutation is its effect on
fitness. Stress is a reduction in fitness that can also alter the selection on new mutations …

When are mutations beneficial in one environment and deleterious in another? More
generally, what is the relationship between mutation effects across environments? These …

Lactic acid bacteria (LAB) are well known to elicit health benefits in humans, but their
functional metabolic landscapes remain unexplored. Here, we analyze differences in …

Understanding the evolution of biological systems requires untangling the molecular
mechanisms that connect genetic and environmental variations to their physiological …

The role of mutations in evolution depends upon the distribution of their effects on fitness.
This distribution is likely to depend on the environment. Indeed genotype-by-environment …

Bacterial resistance to antibiotics usually incurs a fitness cost in the absence of selecting
drugs, and this cost of resistance plays a key role in the spread of antibiotic resistance in …

Growth rate is an important variable and parameter in biology with a central role in
evolutionary, functional genomics, and systems biology studies. In this review the pros and …