Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Plant-derived functional foods are gaining considerable attention due to their safety and
therapeutic potentials. Research on plant-based functional foods presents several …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Background Mitochondria, the power plants of the cell, are known as a cross-road of
different cellular signaling pathways. These cytoplasmic double-membraned organelles play …

Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …

Acetaminophen (APAP), which is also known as paracetamol or N-acetyl-p-aminophenol is
a safe and potent drug for fever, pain and inflammation when used at its normal therapeutic …

Being the most essential organ in the body, the liver performs critical functions. Hepatic
disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty …

Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the United
States and APAP-induced hepatotoxicity is initiated by formation of a reactive metabolite …