Over the past 20 years there has been an increasing number of brain imaging studies on the
mechanisms underlying reward motivation in humans. This narrative review describes …

The original concept of consolidation considers that memory requires time to be fixed. Since
2000, a comparable protein-dependent re-stabilization phase, called reconsolidation, has …

The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans
and to reinstatement in rodent models of cocaine use disorder. Output from the mPFC is …

Systematic investigation of reactivation-induced memory updating began in the 1960s, and
a wave of research in this area followed the seminal articulation of “reconsolidation” theory …

Substance-related disorders are complex psychiatric disorders that are characterized by
continued consumption in spite of harmful consequences. Addiction affects various brain …

Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-
associated memories. Memories are thought to temporarily destabilize upon retrieval during …

Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been
implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation …

Adolescents are at increased risk to develop substance use disorders and suffer from
relapse throughout life. Targeted weakening of drug-associated memories has been shown …

Background Relapse, often precipitated by drug-associated cues that evoke craving, is a key
problem in the treatment of methamphetamine use disorder (MUD). Drug-associated …