LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

NR2A and NR2B are the predominant NR2 NMDA receptor subunits expressed in cortex
and hippocampus. The relative expression level of NR2A and NR2B is regulated …

The N-methyl-d-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion
channel that interacts with multiple intracellular proteins by way of different subunits. NMDA …

Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …

Protein synthesis-dependent, synapse input-specific late phases of long-term potentiation
(LTP) and depression (LTD) may underlie memory formation at the cellular level. Recently, it …

The role of NMDA receptors in the induction of long-term potentiation (LTP) and long-term
depression (LTD) is well established but which particular NR2 subunits are involved in these …