Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …

DNA demethylation can occur passively by “dilution” of methylation marks by DNA
replication, or actively and independently of DNA replication. Direct conversion of 5 …

Base excision repair (BER) is one of several DNA repair pathways found in all three
domains of life. BER counters the mutagenic and cytotoxic effects of damage that occurs …

DNA demethylation is an essential cellular activity to regulate gene expression; however,
the mechanism that triggers DNA demethylation remains unknown. Furthermore, DNA …

AID/APOBEC family enzymes are best known for deaminating cytosine bases to uracil in
single-stranded DNA, with characteristic sequence preferences that can produce mutational …

Endogenous and exogenous reactive species cause oxidatively induced DNA damage in
living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or …

Pathways that control and modulate DNA methylation patterning in mammalian cells were
poorly understood for a long time, although their importance in establishing and maintaining …

Growth arrest and DNA damage 45 (Gadd45) family genes, Gadd45A, Gadd45B, and
GADD45 G are implicated as stress sensors that are rapidly induced upon genotoxic …

The integrity of the genetic information is continuously challenged by numerous genotoxic
insults, most frequently in the form of oxidation, alkylation or deamination of the bases that …