Coordination of circadian timing in mammals

SM Reppert, DR Weaver - Nature, 2002 - nature.com
Time in the biological sense is measured by cycles that range from milliseconds to years.
Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most …

Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors

A Sancar - Chemical reviews, 2003 - ACS Publications
Photoreactivation1, 2 is the reversal of the harmful effects, such as growth delay,
mutagenesis, and killing, of far UV (200-300 nm) on organisms by concurrent or subsequent …

Phototransduction by retinal ganglion cells that set the circadian clock

DM Berson, FA Dunn, M Takao - Science, 2002 - science.org
Light synchronizes mammalian circadian rhythms with environmental time by modulating
retinal input to the circadian pacemaker—the suprachiasmatic nucleus (SCN) of the …

An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans

K Thapan, J Arendt, DJ Skene - The Journal of physiology, 2001 - Wiley Online Library
1 Non‐image forming, irradiance‐dependent responses mediated by the human eye include
synchronisation of the circadian axis and suppression of pineal melatonin production. The …

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).

A Sancar - Angewandte Chemie International Edition, 2016 - search.ebscohost.com
The article presents the result of a study which examined DNA repair through photolyase in
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …

Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice

S Hattar, RJ Lucas, N Mrosovsky, S Thompson… - Nature, 2003 - nature.com
In the mammalian retina, besides the conventional rod–cone system, a melanopsin-
associated photoreceptive system exists that conveys photic information for accessory visual …

Intrinsically photosensitive retinal ganglion cells

MTH Do, KW Yau - Physiological reviews, 2010 - journals.physiology.org
Life on earth is subject to alternating cycles of day and night imposed by the rotation of the
earth. Consequently, living things have evolved photodetective systems to synchronize their …

Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting

S Panda, TK Sato, AM Castrucci, MD Rollag… - Science, 2002 - science.org
The master circadian oscillator in the hypothalamic suprachiasmatic nucleus is entrained to
the day/night cycle by retinal photoreceptors. Melanopsin (Opn4), an opsin-based …

Time zones: a comparative genetics of circadian clocks

MW Young, SA Kay - Nature Reviews Genetics, 2001 - nature.com
The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic
functions in organisms from bacteria and fungi, to plants and animals. Intense genetic …

Characterization of an ocular photopigment capable of driving pupillary constriction in mice

RJ Lucas, RH Douglas, RG Foster - Nature neuroscience, 2001 - nature.com
This work demonstrates that transgenic mice lacking both rod and cone photoreceptors
(rd/rd cl) retain a pupillary light reflex (PLR) that does not rely on local iris photoreceptors …