Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

[HTML][HTML] Latest views on the mechanisms of action of surgically implanted cervical vagal nerve stimulation in epilepsy

R Carron, P Roncon, S Lagarde, M Dibué… - … : Technology at the …, 2023 - Elsevier
Background Vagus nerve stimulation (VNS) is approved as an adjunctive treatment for drug-
resistant epilepsy. Although there is a substantial amount of literature aiming at unraveling …

Transcutaneous auricular vagus nerve stimulation (taVNS) for migraine: an fMRI study

Y Zhang, Y Huang, H Li, Z Yan, Y Zhang… - Regional Anesthesia & …, 2021 - rapm.bmj.com
Background Dysfunction of the thalamocortical connectivity network is thought to underlie
the pathophysiology of the migraine. This current study aimed to explore the thalamocortical …

[HTML][HTML] Evolution of the vagus nerve stimulation (VNS) therapy system technology for drug-resistant epilepsy

P Afra, B Adamolekun, S Aydemir… - Frontiers in Medical …, 2021 - frontiersin.org
The vagus nerve stimulation (VNS) Therapy® System is the first FDA-approved medical
device therapy for the treatment of drug-resistant epilepsy. Over the past two decades, the …

[HTML][HTML] Effects of stimulus frequency, intensity, and sex on the autonomic response to transcutaneous vagus nerve stimulation

H Yokota, M Edama, R Hirabayashi, C Sekine… - Brain sciences, 2022 - mdpi.com
This study aimed to determine how transcutaneous vagus nerve stimulation (tVNS) alters
autonomic nervous activity by comparing the effects of different tVNS frequencies and …

Connectomic profiling identifies responders to vagus nerve stimulation

K Mithani, M Mikhail, BR Morgan, S Wong… - Annals of …, 2019 - Wiley Online Library
Objective Vagus nerve stimulation (VNS) is a common treatment for medically intractable
epilepsy, but response rates are highly variable, with no preoperative means of identifying …

Closed-loop neurostimulation for the treatment of psychiatric disorders

KK Sellers, JL Cohen, AN Khambhati, JM Fan… - …, 2024 - nature.com
Despite increasing prevalence and huge personal and societal burden, psychiatric diseases
still lack treatments which can control symptoms for a large fraction of patients. Increasing …

Biomarkers of seizure response to vagus nerve stimulation: a scoping review

AM Workewych, ON Arski, K Mithani, GM Ibrahim - Epilepsia, 2020 - Wiley Online Library
Although vagus nerve stimulation (VNS) is a common procedure, seizure outcomes are
heterogeneous, with few available means to preoperatively identify the ideal surgical …

Vagal sensory neurons and gut-brain signaling

DY Chuyue, QJ Xu, RB Chang - Current opinion in neurobiology, 2020 - Elsevier
Highlights• The vagus nerve is a crucial link between gut signals and the brain regulating
various functions such as energy homeostasis, digestion, immune responses, reward …

[HTML][HTML] Entropy in scalp EEG can be used as a preimplantation marker for VNS efficacy

B Sklenárová, J Chládek, M Macek, M Brázdil… - Scientific Reports, 2023 - nature.com
Vagus nerve stimulation (VNS) is a therapeutic option in drug-resistant epilepsy. VNS leads
to≥ 50% seizure reduction in 50 to 60% of patients, termed" responders". The remaining 40 …