Objective: To review the pharmacology, pharmacokinetics, clinical investigations, and
adverse effects of sulpiride as a treatment for schizophrenia. Data Sources: Information was …

Several hypotheses regarding the physiopathology of major depression exist. Attention has
been focused on cerebral monoaminergic systems, the dysfunction of which is thought to …

There is some experimental evidence suggesting that temporal processing of brief duration
in the range of milliseconds is based on dopamine (DA)-dependent neural counting …

Individual differences in the behavioral approach system (BAS)—referred to as trait
approach motivation or trait BAS)—have been linked to both frontal electroencephalogram …

The cognitive enhancing effects of methylphenidate are well established, but the
mechanisms remain unclear. We recently demonstrated that methylphenidate boosts …

Sulpiride is a substituted benzamide with a selective action on receptors of the dopamine D
2-like family, and clinical and pharmacological data suggest that it could be considered to be …

In modeling blood–brain barrier (BBB) passage, in silico models have yielded~ 80%
prediction accuracy, and are currently used in early drug discovery. Being derived from …

In this paper the historical and scientific background that led to the use of substituted
benzamides in two apparently unrelated clinical conditions namely dysthymic disorder and …

Dopamine has been suggested to have direct antinociceptive effects. However, effects on
the motivation to endure or to avoid nociceptive stimulation would be more in line with …

Cannabis and analogs of Δ9-tetrahydrocannabinol have been used for therapeutic
purposes, but their therapeutic use remains limited because of various adverse effects …