Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

Computational modeling has contributed significantly to present understanding of cardiac
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …

Intracellular calcium (Ca) cycling in the heart plays key roles in excitation–contraction
coupling and arrhythmogenesis. In cardiac myocytes, the Ca release channels, ie, the …

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is sustained by
spontaneous focal excitations and re‐entry. Spontaneous electrical firing in the pulmonary …

The goal of the CiPA initiative (Comprehensive in vitro Proarrhythmia Assay) was to assess
a more accurate prediction of new drug candidate proarrhythmic severe liabilities such as …

Chronic exposure to low levels of Carbon Monoxide is associated with an increased risk of
cardiac arrhythmia. Microelectrode recordings from rat and guinea pig single isolated …

The intracellular calcium handling system of cardiomyocytes is responsible for controlling
excitation-contraction coupling (ECC) and has been linked to pro-arrhythmogenic cellular …

Short QT syndrome (SQTS) is a genetic disease characterized by constantly short QT
intervals and high risks of sudden death. SQTS6 is one of the identified SQTS genotype …

The objective of this paper is to develop a computationally efficient simulation model of
Calcium signalling in cardiomyocytes. The model considered here consists of more than two …

The development of modeling structures at the channel level that can integrate subcellular
and cell models and properly reproduce different experimental data is of utmost importance …