Neutrophils are critical to innate immunity, including host defense against bacterial and
fungal infections. They achieve their host defense role by phagocytosing pathogens …

As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and
have pathogenic functions in diverse diseases. We examined the NETosis pathways …

Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …

PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and
oncological diseases through clinical genetics and gene disruption in mice. New selective …

Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Citrullination is the post-translational conversion of an arginine residue within a protein to
the non-coded amino acid citrulline. This modification leads to the loss of a positive charge …

Conspectus Proteins are well-known to undergo a variety of post-translational modifications
(PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group …

Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

Human proteins are subjected to more than 200 known post-translational modifications
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …