The genetics and neuropathology of Alzheimer's disease
GD Schellenberg, TJ Montine - Acta neuropathologica, 2012 - Springer
Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …
Genetic markers of Alzheimer's disease
M Nikolac Perkovic, N Pivac - Frontiers in Psychiatry: Artificial Intelligence …, 2019 - Springer
Alzheimer's disease is a complex and heterogeneous, severe neurodegenerative disorder
and the predominant form of dementia, characterized by cognitive disturbances, behavioral …
and the predominant form of dementia, characterized by cognitive disturbances, behavioral …
Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …
Cryo-EM structures of amyloid-β 42 filaments from human brains
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in
Alzheimer's disease. Here, we report the cryo–electron microscopy (cryo-EM) structures of …
Alzheimer's disease. Here, we report the cryo–electron microscopy (cryo-EM) structures of …
Single App knock-in mouse models of Alzheimer's disease
T Saito, Y Matsuba, N Mihira, J Takano, P Nilsson… - Nature …, 2014 - nature.com
Experimental studies of Alzheimer's disease have largely depended on transgenic mice
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial …
APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release
Sequential proteolysis of the amyloid precursor protein (APP) by γ‐secretases generates
amyloid‐β (Aβ) peptides and defines the proportion of short‐to‐long Aβ peptides, which is …
amyloid‐β (Aβ) peptides and defines the proportion of short‐to‐long Aβ peptides, which is …
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease
Objective: To investigate CSF markers involved in amyloid precursor protein processing,
neuronal damage, and neuroinflammation in the preclinical stages of Alzheimer disease …
neuronal damage, and neuroinflammation in the preclinical stages of Alzheimer disease …
Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies
M Colom-Cadena, E Gelpi, S Charif… - … of Neuropathology & …, 2013 - academic.oup.com
Dementia with Lewy bodies (DLB) is pathologically characterized by α-synuclein aggregates
in the brain. Most patients with DLB also show cerebral Alzheimer disease-type pathology …
in the brain. Most patients with DLB also show cerebral Alzheimer disease-type pathology …
Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
Introduction Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in
Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the …
Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the …
Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice
A Locci, H Orellana, G Rodriguez, M Gottliebson… - Behavioural brain …, 2021 - Elsevier
Transgenic mouse models of Aβ amyloidosis generated by knock-in of a humanized Aβ
sequence can offer some advantages over the transgenic models that overexpress amyloid …
sequence can offer some advantages over the transgenic models that overexpress amyloid …