[HTML][HTML] The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology

J Vallin, J Grantham - Cell Stress and Chaperones, 2019 - Elsevier
The chaperonin-containing tailless complex polypeptide 1 (CCT) is required in vivo for the
folding of newly synthesized tubulin and actin proteins and is thus intrinsically connected to …

Quality control of cytoskeletal proteins and human disease

VF Lundin, MR Leroux, PC Stirling - Trends in biochemical sciences, 2010 - cell.com
Actins and tubulins are abundant cytoskeletal proteins that support diverse cellular
processes. Owing to the unique properties of these filament-forming proteins, an intricate …

Endogenous retroviruses shape pluripotency specification in mouse embryos

S de la Rosa, M del Mar Rigual, P Vargiu, S Ortega… - Science …, 2024 - science.org
The smooth and precise transition from totipotency to pluripotency is a key process in
embryonic development, generating pluripotent stem cells capable of forming all cell types …

[HTML][HTML] Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction

A Locascio, MA Blázquez, D Alabadí - Current Biology, 2013 - cell.com
Plant morphogenesis relies on specific patterns of cell division and expansion. It is well
established that cortical microtubules influence the direction of cell expansion [1, 2], but less …

Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane

Y Salanenka, I Verstraeten, C Löfke… - Proceedings of the …, 2018 - National Acad Sciences
The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development.
The main paradigm of GA signaling puts forward transcriptional regulation via the …

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

A Noormohammadi, A Khodakarami… - Nature …, 2016 - nature.com
Human embryonic stem cells can replicate indefinitely while maintaining their
undifferentiated state and, therefore, are immortal in culture. This capacity may demand …

A chromosome‐level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth

Y He, Y Chang, L Bao, M Yu, R Li, J Niu… - Molecular ecology …, 2019 - Wiley Online Library
The black rockfish (Sebastes schlegelii) is a teleost in which eggs are fertilized internally
and retained in the maternal reproductive system, where they undergo development until …

Nuclear functions of prefoldin

G Millán-Zambrano, S Chávez - Open biology, 2014 - royalsocietypublishing.org
Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin
CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and …

Prefoldin function in cellular protein homeostasis and human diseases

I Tahmaz, S Shahmoradi Ghahe, U Topf - Frontiers in cell and …, 2022 - frontiersin.org
Cellular functions are largely performed by proteins. Defects in the production, folding, or
removal of proteins from the cell lead to perturbations in cellular functions that can result in …

Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression

D Wang, W Shi, Y Tang, Y Liu, K He, Y Hu, J Li, Y Yang… - Oncogene, 2017 - nature.com
Prefoldin (PFDN) is a co-chaperone protein that is primarily known for its classic cytoplasmic
functions in the folding of actin and tubulin monomers during cytoskeletal assembly. Here …