The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Salt and cocrystal formation are the most commonly used method of increasing solubility
and dissolution rate of pharmaceutical compounds, and are of particular interest for …

Crystallization is crucial in the pharmaceutical industry as a separation process for
intermediates and as the final step in the manufacture of active pharmaceutical ingredients …

Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …

Highlights•Multi-drug co-crystals would offer an efficient solution to combat various
diseases.•Cocrystals would play vital role in market due to expanded patent …

The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal
engineering that has emerged as a promising technique for drug development in …

Co-crystallization is the supramolecular phenomenon of aggregation of two or more different
chemical entities in a crystalline lattice through non-covalent interactions. It encompasses …

Objectives We provide a brief overview of recent applications of cocrystals for improving the
physico-chemical and materials properties of active pharmaceutical ingredients, including …

Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …

A series of nine complexes and 109 literature examples containing a carboxylic acid
functional group and a pyridine functional group on separate molecules follow the ΔpKa rule …