Flavonoids are natural plant-derived dietary bioactive compounds having a substantial
impact on human health. Morin hydrate is a bioflavonoid mainly obtained from fruits, stem …

Acetaminophen (APAP) is a widely used analgesic and antipyretic over-the-counter
medicine worldwide. Hepatotoxicity caused by APAP overdose is one of the leading causes …

Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …

Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Introduction Herbal traditional medicines are used for the treatment of human diseases and
associated complications from the medieval periods. Flavonoids are naturally occurring …

Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality
control system for cellular proteins as it is intricately involved in their synthesis, folding and …

Amygdalin is a natural compound from Bitter Apricot Seed which is reported to have anti-
inflammatory activity. Acetaminophen (APAP) resulted in drug-induced liver injury is the …

Hyperglycemia associated ER stress has been found as a critical contributor in the
pathogenesis of type 2 diabetes mellitus. However, reports regarding molecular …

Scope Although the previous trials of inflammation have indicated that morin hydrate (MO)
hold considerable promise, understanding the distinct mechanism of MO against …

Abstract NF-E2 p45-related factor 2 (Nrf2), is a major redox sensitive transcription factor that
plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been …