Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …

Objective To describe a new entity of congenital muscular dystrophies caused by de novo
LMNA mutations. Methods Fifteen patients presenting with a myopathy of onset in the first …

The main function of the nuclear lamina, an intermediate filament meshwork lying primarily
beneath the inner nuclear membrane, is to provide structural scaffolding for the cell nucleus …

The laminopathies are a diverse group of conditions caused by mutations in the LMNA gene
(MIM* 150330). LMNA encodes the nuclear envelope proteins lamin A and lamin C by …

Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as
laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is …

In eukaryotes, the function of the cell's nucleus has primarily been considered to be the
repository for the organism's genome. However, this rather simplistic view is undergoing a …