Parasitic infections induce host immune responses that eliminate the invading parasites.
However, parasites have evolved to develop many strategies to evade host immune attacks …

American Trypanosomiasis is an important neglected reemerging tropical parasitism,
infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple …

For many years it has been considered that there are three basic developmental stages of
Trypanosoma cruzi: Epimastigote (Epi), Amastigote (Ama) and Trypomastigote (Typo). Epi …

Chagas disease is a neglected infectious disease caused by the protozoan Trypanosoma
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …

Calreticulin from parasites and its vertebrate hosts share~ 50% identity and many of its
functions are equally conserved. However, the existing amino acid differences can affect its …

Because of its capacity to increase a physiologic inflammatory response, to stimulate
phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the …

Chagas' disease is a zoonotic parasitic ailment now affecting more than 6 million people,
mainly in Latin America. Its agent, the protozoan Trypanosoma cruzi, is primarily transmitted …

To successfully infect, Trypanosoma cruzi evades and modulates the host immune
response. T. cruzi calreticulin (TcCalr) is a multifunctional, endoplasmic reticulum (ER) …

BACKGROUND Trypanosoma cruzi is a protozoan parasite and an etiological agent of
Chagas disease. There is a wide variability in the clinical outcome of its infection, ranging …

Trypanosoma cruzi calreticulin (TcCalr, formerly known as TcCRT), upon binding to
Complement (C) C1 and ficolins, inhibits the classical and lectin pathways and promotes …