The physiological role of estrogen in the female endometrium is well established. On the
basis of responses to steroid hormones (progesterone, androgen, and estrogen), the …

The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

Estradiol (E2) is a major hormone controlling women fertility, in particular folliculogenesis.
This steroid, which is locally produced by granulosa cells (GC) within ovarian follicles …

Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and
reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled …

The progesterone hormone regulates the human menstrual cycle, pregnancy, and
parturition by its action via the different progesterone receptors and signaling pathways in …

STUDY QUESTION Is polycystic ovary syndrome (PCOS) associated with increased serum
levels of typical organic pollutants? SUMMARY ANSWER PCOS in Han females from …

Polycystic ovary syndrome (PCOS) is a complex, heterogeneous endocrine and metabolic
disorder affecting 5% to 10% of reproductive-age women. A high rate of granulosa cell (GC) …

Objective Gut microbiota and its metabolites have regulatory effects on PCOS related
ovarian dysfunction and insulin resistance. Escherichia coli Nissle 1917 (EcN) is a …

Purpose We aimed to evaluate the regulation of miR-99a to the biological functions of
granulosa cells in polycystic ovary syndrome (PCOS) via targeting IGF-1R. Methods We …

Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of
reproductive age. MicroRNAs (miRNAs or miRs) serve important roles in the physiological …