Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

Luminescent probes and nanoparticles (NPs) with long excited state lifetimes are essential
for time-resolved biological imaging. Generally, cell membranes are physiological barriers …

The translational therapies to promote interaction between cell and signal come with
stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet …

Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Non-viral gene delivery vectors have lagged far behind viral ones in the current pipeline of
clinical trials of gene therapy nanomedicines. Even when non-viral nanovectors pose less …

Nucleic acid therapeutics have emerged as one of the very advanced and efficacious
treatment approaches for debilitating health conditions, including those diseases affecting …

Nanotechnology approaches play an important role in developing novel and efficient
carriers for biomedical applications. Peptides are particularly appealing to generate such …