Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the
inner ear. Due to their popular application as a result of their potent antimicrobial activities …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

5. Mechanisms of Transduction and Excitation in the Cochlea.. 1 1 2 A. Introduction.......... 1 1
2 B. The cytoskeleton of the transducer region..... 1 1 3 C. Mechanisms of transduction....... 1 …

After almost seven decades in clinical use, aminoglycoside antibiotics still remain
indispensible drugs for acute infections and specific indications such as tuberculosis or the …

Understanding underlying pathological mechanisms is prerequisite for a sensible design of
protective therapies against hearing loss. The triad of age-related, noise-generated, and …

Cisplatin is used to treat a variety of solid tumors in both children and adults. However,
cisplatin has serious side-effects, some of which may permanently affect patients' quality of …

Protection of hair cells by HSP70 released by supporting cells is reported by May et al. in
this issue of the JCI. Their findings suggest a new way to reduce ototoxicity from therapeutic …

This study provides transcriptomic characterization of the cells of the crista ampullaris,
sensory structures at the base of the semicircular canals that are critical for vestibular …

Sensorineural hearing loss is a normal consequence of aging and results from a variety of
extrinsic challenges such as excessive noise exposure and certain therapeutic drugs …

Here we study links between aminoglycoside-induced mistranslation, protein misfolding and
neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells …