TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
Conflicts over calcium and the treatment of COVID-19
Several recent studies have provided evidence that use of calcium channel blockers
(CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus …
(CCBs), especially amlodipine and nifedipine, can reduce mortality from coronavirus …
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …
coronavirus 2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation …
Dysregulation of host cell calcium signaling during viral infections: Emerging paradigm with high clinical relevance
Viral infections are one of the leading causes of human illness. Viruses take over host cell
signaling cascades for their replication and infection. Calcium (Ca 2+) is a versatile and …
signaling cascades for their replication and infection. Calcium (Ca 2+) is a versatile and …
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods
Attachment to and fusion with cell membranes are two major steps in the replication cycle of
many human viruses. We focus on these steps for three enveloped viruses, ie, HIV-1, IAVs …
many human viruses. We focus on these steps for three enveloped viruses, ie, HIV-1, IAVs …
Drug repurposing against SARS-CoV-1, SARS-CoV-2 and MERS-CoV
Since the beginning of the COVID-19 pandemic, large in silico screening studies and
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …
SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells
K Yang, S Liu, H Yan, W Lu, X Shan, H Chen… - … and Targeted Therapy, 2023 - nature.com
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …
Dynamic Ca2+ sensitivity stimulates the evolved SARS-CoV-2 spike strain-mediated membrane fusion for enhanced entry
Mutations in the spike protein generated a highly infectious and transmissible D614G
variant, which is present in newly evolved fast-spreading variants. The D614G, Alpha, Beta …
variant, which is present in newly evolved fast-spreading variants. The D614G, Alpha, Beta …