Abstract The US Food and Drug Administration (FDA) approved 5-aminolevulinic acid (5-
ALA; Gleolan®; photonamic GmbH and Co. KG) for use as an intraoperative optical imaging …

Radiographic endpoints including response and progression are important for the
evaluation of new glioblastoma therapies. The current RANO criteria was developed to …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
and compare currently approved drugs for treatment of glioblastoma multiforme (GBM) and …

Purpose Concomitant temozolomide (TMZ)/radiotherapy followed by adjuvant TMZ has
increased survival in patients with glioblastoma multiforme (GBM). However, few options are …

Angiogenesis—one of the hallmarks of cancer—has emerged as a valid therapeutic target in
oncology. The VEGF system represents a key mediator of tumor-initiated angiogenesis and …

Purpose: Patients with central nervous system (CNS) metastases were excluded from
bevacizumab trials following a case of fatal cerebral hemorrhage in a patient with …

Glioblastoma is the most frequent and devastating primary malignant brain tumor in adults.
Surgery followed by standard radiotherapy with concomitant and adjuvant chemotherapy …