Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …

Abstract Structure determination of membrane proteins is critical to the molecular
understanding of many life processes, yet it has historically been a technically challenging …

Structure-based drug discovery (SBDD) is an indispensable approach for the design and
optimization of new therapeutic agents. Here, we highlight the rapid progress that has turned …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

Changing Form and Function through Carotenoids and Synthetic Biology | Plant Physiology |
Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals Books …

Gap junctions establish direct pathways for cells to transfer metabolic and electrical
messages. The local lipid environment is known to affect the structure, stability and …

Macromolecular protein assemblies are of fundamental importance for many processes
inside the cell, as they perform complex functions and constitute central hubs where …

Highlights•Single-particle cryoEM facilitates structural determination of membrane proteins
without the need of crystallization.•Advances in membrane protein sample preparation are …