The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …

The regulation of the immune microenvironment within solid tumors has received increasing
attention with the development and clinical success of immune checkpoint blockade …

Airway smooth muscle cell contraction is regulated by changes in intracellular Ca2+
concentration ([Ca2+] i) and the responsiveness of the airway smooth muscle cell to this …

CD38, a membrane protein expressed in airway smooth muscle (ASM) cells, plays a role in
cellular Ca2+ dynamics and ASM contractility. In human ASM (HASM) cells, TNF-α induces …

Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …

Asthma is characterized by airway hyperresponsiveness and airway remodeling, which are
largely attributed to increased airway smooth muscle contractility and cell proliferation. It is …

Contractility of airway smooth muscle requires elevation of intracellular calcium
concentration. Under resting conditions, airway smooth muscle cells maintain a relatively …

We have previously shown that long-term treatment of airway smooth muscle (ASM) cells
with a combination of TNF-α and IFN-γ impaired steroid anti-inflammatory action through the …

Immune-mediated pulmonary diseases are a group of diseases that resulted from immune
imbalance initiated by allergens or of unknown causes. Inflammatory responses without …