Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation,
autoimmune diseases, and cancer. To exert their broad physiological and therapeutic …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The characterization of the subfamily of steroid hormone receptors has enhanced our
understanding of how a set of hormonally derived lipophilic ligands controls cellular and …

Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is
mediated by a superfamily of transport receptors known collectively as karyopherins …

Nuclear receptors are central to the regulation of development, endocrine signalling and
metabolism. The transcriptional activity of many receptors is controlled through the binding …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

The last decade has witnessed tremendous progress in the understanding of the
mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for …

In eukaryotic cells, the movement of macromolecules between the nucleus and cytoplasm
occurs through the nuclear pore complex (NPC)—a large protein complex spanning the …

The mineralocorticoid receptor (MR) integrates hormonal signaling and activates the
expression of aldosterone target genes, which control various physiological processes. In …

The c-Jun N-terminal kinase (JNK) phosphorylates the glucocorticoid receptor (GR) and
inhibits GR-mediated transcription. However, the biological effect of the GR phosphorylation …